ACUTE MYELOGENOUS LEUKEMIA (AML)
Also called acute myeloid leukemia or acute nonlymphocytic leukemia (ANLL). It is a quickly progressive malignant disease in which there are too many immature blood-forming cells in the blood and bone marrow. AML can occur in adults or children. The early signs of AML may be similar to the flu or other common diseases with fever, weakness and fatigue, loss of weight and appetite, and aches and pains in the bones or joints. Other signs of AML may include tiny red spots in the skin, easy bruising and bleeding, frequent minor infections, and poor healing of minor cuts. Listed below are the most common chromosome changes observed in AML patients.
• t(8;21)(q22;q22) ETO/AML
• t(15;17)(q24;q21.2) PML/RARA
• inv(16)(p13q22)/t(16;16)(p13;q22) CBFB/MYH11
• trisomy 8
•11q23 rearrangement KMT2A
• t(9;11)(p21;a23) KMT2A/MLLT3
• t(6;11)(q27;q23) KMT2A/AFDN
• t(11;19)(q23;p13.3) KMT2A/MLLT1
• t(6;9)(p22;q34) DEK/NUP214
• -5/5q- EGR1/D5S721
• -7/7q- CEP7/D7S486
FISH analysis can be performed to confirm diagnosis and/or monitor chromosome changes during treatment. Clinicians can order individual probes or the complete AML panel. Please refer to the Cytogenetics for Hematology/Oncology Disorders test order form to order testing and to review the specimen requirements.
Karyotype analysis can also be performed to confirm the FISH results.
OUHSC Genetics Laboratory 1122 NE 13th Street, Suite 1400, Oklahoma City, OK 73104
Phone (405)271-3589 Fax (405)271-7117 After hours phone (405)496-9514
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