CHRONIC MYELOGENOUS LEUKEMIA (CML)
Chronic myelogenous leukemia is commonly called CML. It is also known as chronic myelocytic leukemia and chronic granulocytic leukemia. CML is a chronic malignant disease in which too many white blood cells belonging to the myeloid line of cells are made in the bone marrow. Early symptoms of this form of leukemia include fatigue, night sweats, fever, lack of appetite, and the spleen may be swollen and markedly enlarged.
CML is caused by a chromosome abnormality called the Philadelphia chromosome. Discovered in 1960, the Philadelphia chromosome is an abnormally short chromosome 22 that is one of the two chromosomes involved in a translocation with chromosome 9. This translocation takes place in a single bone marrow cell and, through the production of many cells from this one mutant cell, it gives rise to the leukemia. FISH analysis for t(9;22)(q34;q11.2) is performed for this disease.
FISH analysis can be performed to confirm diagnosis and/or monitor chromosome changes during treatment. Please refer to the Cytogenetics for Hematology/Oncology Disorders test order form to order testing and to review the specimen requirements.
Karyotype analysis can also be performed to confirm the FISH results.
OUHSC Genetics Laboratory 1122 NE 13th Street, Suite 1400, Oklahoma City, OK 73104
Phone (405)271-3589 Fax (405)271-7117 After hours phone (405)496-9514
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