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MYELOPROLIFERATIVE NEOPLASMS

The myeloproliferative neoplasms are a group of diseases that cause platelets, white blood cells and red blood cells to grow abnormally in the bone marrow. This may cause bleeding issues, anemia, infection or fatigue. Myeloproliferative disorders include polycythemia vera, essential thrombocytosis, myelofibrosis, CML and chronic eosinophilic leukemia. Over time some of the myeloproliferative neoplasms may evolve into AML.

Common chromosome changes associated with myeloproliferative neoplasms are listed below.

t(9;22)(q34;q11.2) BCR/ABL1

4q12 rearrangement FIPIL1/PDGFRA

5q33 rearrangement PDGFRB

8p11 rearrangement FGFR1

FISH analysis can be performed to confirm diagnosis and/or monitor chromosome changes during treatment. Clinicians can order individual probes or the complete panel. Please refer to the Cytogenetics for Hematology/Oncology test order form to order testing and to review specimen requirements.

Karyotype analysis can also be performed to confirm the FISH results.

Cytogenetics for Hematology/Oncology Test Order Form

 

 

 


 

 

Contact Information

OUHSC Genetics Laboratory 1122 NE 13th Street, Suite 1400, Oklahoma City, OK 73104

Phone (405)271-3589 Fax (405)271-7117 After hours phone (405)496-9514

   


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