NON-HODGKIN LYMPHOMAS (NHL)
Lymphoma is cancer that begins in infection-fighting cells of the immune system, called lymphocytes. These cells are in the lymph nodes, spleen, thymus, bone marrow, and other parts of the body. When you have lymphoma, lymphocytes change and grow out of control. There are two main types of lymphoma: Non-Hodgkin and Hodgkin. Most people with lymphoma are diagnosed with the Non-Hodgkin form of the disease.
There are many different sub-types of Non-Hodgkin lymphoma; large cell, small cell, mixed cell, mantle cell, and Burkitts lymphoma just to name a few. Every type of lymphoma grows at a different rate and responds differently to treatment. Common chromosome changes associated with NHL are listed below.
• 8q24 rearrangement MYC
• t(8;14)(q24;q32) IGHG1/MYC
• t(11;14)(q13;q32) IGHG1/CCND1
• t(14;18)(q32;q21) IGHG1/MALT1
• t(14;18)(q32;q21) IGHG1/BCL2
• 3q27 rearrangement BCL6
• 18q21 rearrangement MALT1
• 18q21 rearrangement BCL2
• t(18;18)(q21;q21) BIRC3/MALT1
• 2p23 rearrangement ALK
FISH analysis can be performed to confirm diagnosis and/or monitor chromosome changes during treatment. Clinicians can order individual probes or the complete NHL panel. Please refer to the Cytogenetics for Hematology/Oncology test order form to order testing and to review specimen requirements.
Karyotype analysis can also be performed to confirm the FISH results.
OUHSC Genetics Laboratory 1122 NE 13th Street, Suite 1400, Oklahoma City, OK 73104
Phone (405)271-3589 Fax (405)271-7117 After hours phone (405)496-9514
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