T-cell ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL)
T-ALL is a form of lymphoid leukemia and lymphoma in which too many T-cell lymphoblasts (immature white blood cells) are found in the blood, bone marrow, and tissues, particularly mediastinal lymph nodes. Labeling as leukemia or lymphoma depends on which feature is more pronounced in a given case, but has no biological or treatment implication. It is uncommon in adults, but represents 15% of childhood acute lymphoblastic leukemia and 90% of lymphoblastic lymphoma cases.
Patients may present with anemia, weakness, fatigue, shortness of breath, light-headedness, palpitations, frequent infections, fever, easy bruising, nosebleeds, bleeding gums, and swollen lymph nodes.
Common chromosome changes associated with multiple myeloma are listed below.
• t(9;22)(q34;q11.2) BCR/ABL1
• 11q23 rearrangement KMT2A
• inv(14)(q11q32.1)/(14;14)(q11;q32.1) TRA-TRD/TCL1A
• inv(7)(p15;q34)/t(7;7)(p15;q34) TRB/HOXA10
• Xq28 rearrangement MTCP1/T-PLL
FISH analysis can be performed to confirm diagnosis and/or monitor chromosome changes during treatment. Clinicians can order individual probes or the complete panel. Please refer to the Cytogenetics for Hematology/Oncology test order form to order testing and to review specimen requirements.
Karyotype analysis can also be performed to confirm the FISH results.
OUHSC Genetics Laboratory 1122 NE 13th Street, Suite 1400, Oklahoma City, OK 73104
Phone (405)271-3589 Fax (405)271-7117 After hours phone (405)496-9514
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