It is also called acute lymphoblastic leukemia or acute
lymphocytic leukemia and is abbreviated as ALL. It is
a rapidly progressing form of
leukemia that is characterized by the presence
of large numbers of unusually immature white blood cells
destined to become lymphocytes.
Some factors associated with an increased risk of ALL
have been identified. The main environmental factor is
namely prenatal exposure to x-rays or postnatal exposure
to high doses of radiation. Children with Down syndrome
also have an increased risk for both ALL
and acute myeloid leukemia (AML).
Increased occurrence of ALL is also associated with certain
genetic conditions, including neurofibromatosis, Shwachman
syndrome, Bloom syndrome, and ataxia telangiectasia.
Common chromosome changes observed:
MLL 11q23 rearrangement
Methodology: Fluorescent in Situ Hybridization (FISH) Analysis
Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment
ICD-10 Code: C91.10
Test Requisition: Cancer Requisition
Turn-around-time: 2-5 days