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FISH for B-Cell ALL

 

It is also called acute lymphoblastic leukemia or acute lymphocytic leukemia and is abbreviated as ALL. It is a rapidly progressing form of leukemia that is characterized by the presence of large numbers of unusually immature white blood cells destined to become lymphocytes.

Some factors associated with an increased risk of ALL have been identified. The main environmental factor is radiation, namely prenatal exposure to x-rays or postnatal exposure to high doses of radiation. Children with Down syndrome also have an increased risk for both ALL and acute myeloid leukemia (AML). Increased occurrence of ALL is also associated with certain genetic conditions, including neurofibromatosis, Shwachman syndrome, Bloom syndrome, and ataxia telangiectasia.

Common chromosome changes observed:

TEL/AML1  t(12;21)(p13;q11.2)
BCR/ABLt(9;22)(q34;q11.2)
PBX1/TCF3 t(1;19)(q23;p13.2)
p16(CDKN2A)/CEP9 del(9p)
CEP4/CEP10
MLL  11q23 rearrangement
AF4/MLL t(4;11)(q21;q23)
 MLL,ENL t(11;19)(q23;p13.3)

Methodology: Fluorescent in Situ Hybridization (FISH) Analysis

Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment

ICD-10 Code: C91.10

Test Requisition: Cancer Requisition

Turn-around-time: 2-5 days

Specimen Requirements

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Contact Information
Genetics Laboratory
University of Oklahoma Health Sciences Center
1122 NE 13 Street, Suite 1400, Oklahoma City, OK 73104
Phone: (405) 271-3589 |Fax: (405) 271-7117 Email: Dr. Shibo Li

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