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Acute Myeloid Leukemia

 

Also called acute myelogenous leukemia or acute nonlymphocytic leukemia (ANLL). It is a quickly progressive malignant disease in which there are too many immature blood-forming cells in the blood and bone marrow. AML can occur in adults or children.

The early signs of AML may be similar to the flu or other common diseases with fever, weakness and fatigue, loss of weight and appetite, and aches and pains in the bones or joints. Other signs of AML may include tiny red spots in the skin, easy bruising and bleeding, frequent minor infections, and poor healing of minor cuts.

Common chromosome changes observed in AML:

ETO/AML1 t(8;21)(q22;q22)   M2                         
PML/RARA t(15;17)(q22;q21..2)  M3                
CBFbeta  inv(16);t(16;16)      M4        
cen8/c-MYC trisomy 8   M0-M7           
MLL  11q23 rearrangement                                
AF9/MLL  t(9;11)(p22;q23)                   
AF6/MLL  t(6;11)(q27;q23)   
ENL/MLL t(11;19)(q23;p13.3)
DEK/CAN t(6;9)(p23;q34)

Methodology: Fluorescent in Situ Hybridization (FISH) Analysis

Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment

ICD-10 Diagnosis: C92.00, C92.40, C92.50

Test Requisition: Cancer Requisition

Turn-around-time: 2-5 days

Specimen Requirements

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Contact Information
Genetics Laboratory
University of Oklahoma Health Sciences Center
1122 NE 13 Street, Suite 1400, Oklahoma City, OK 73104
Phone: (405) 271-3589 |Fax: (405) 271-7117 Email: Dr. Shibo Li

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