Also called acute myelogenous leukemia or acute nonlymphocytic
leukemia (ANLL). It is a quickly progressive malignant
disease in which there are too many immature blood-forming
in the blood and bone marrow.
AML can occur
in adults or children.
The early signs of AML may be similar to the flu or
other common diseases with fever, weakness and fatigue,
loss of weight and appetite, and aches and pains in the
bones or joints. Other signs of AML may include tiny
red spots in the skin, easy bruising and bleeding, frequent
minor infections, and poor healing of minor cuts.
Common chromosome changes observed in AML:
ETO/AML1 t(8;21)(q22;q22) M2
PML/RARA t(15;17)(q22;q21..2) M3
CBFbeta inv(16);t(16;16) M4
cen8/c-MYC trisomy 8 M0-M7
MLL 11q23 rearrangement
Methodology: Fluorescent in Situ Hybridization (FISH) Analysis
Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment
ICD-10 Diagnosis: C92.00, C92.40, C92.50
Test Requisition: Cancer Requisition
Turn-around-time: 2-5 days