Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in adults, in
which the lymphocytes may look normal but are
mature and do not deal effectively with infection.
Malignant cells, found in the blood and bone marrow,
collect in and enlarge the lymph nodes, and may crowd
out other blood cells in the bone marrow, resulting in
a shortage of red blood cells producing anemia.
CLL is most common in people over 60 and progresses
slowly. In the first stages, there are often no symptoms.
As time goes on, more and more lymphocytes are made and
symptoms begin to appear such as a persistent feeling
of fatigue, swelling of the lymph nodes, enlargement
of the spleen and liver, and easy bruising and bleeding.
Treatment may include chemotherapy, radiation,
removal of the extra lymphocytes, and bone
Common chromosome changes associated with CLL:
MDM2/CEP12 trisomy 12
Methodology: Fluorescent in Situ Hybridization (FISH) Analysis
Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment
ICD-10 Code: C91.10
Test Requisition: Cancer Requisition
Turn-around-time: 2-5 days