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FISH for CLL

 

Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in adults, in which the lymphocytes may look normal but are not fully mature and do not deal effectively with infection. Malignant cells, found in the blood and bone marrow, collect in and enlarge the lymph nodes, and may crowd out other blood cells in the bone marrow, resulting in a shortage of red blood cells producing anemia.

CLL is most common in people over 60 and progresses slowly. In the first stages, there are often no symptoms. As time goes on, more and more lymphocytes are made and symptoms begin to appear such as a persistent feeling of fatigue, swelling of the lymph nodes, enlargement of the spleen and liver, and easy bruising and bleeding. Treatment may include chemotherapy, radiation, removal of the extra lymphocytes, and bone marrow transplantation.

Common chromosome changes associated with CLL:

MYB/6cen -6/del(6q)
ATM/CEP11 -11/del(11q)
MDM2/CEP12  trisomy 12
D13S319/LAMP1 -13/del(13q)
TP53/CEP17  -17/del(17p)
CCND1  t(11;14)
IGHG1/BCL2 t(14;18)

Methodology: Fluorescent in Situ Hybridization (FISH) Analysis

Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment

ICD-10 Code: C91.10

Test Requisition: Cancer Requisition

Turn-around-time: 2-5 days

Specimen Requirements

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Contact Information
Genetics Laboratory
University of Oklahoma Health Sciences Center
1122 NE 13 Street, Suite 1400, Oklahoma City, OK 73104
Phone: (405) 271-3589 |Fax: (405) 271-7117 Email: Dr. Shibo Li

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