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FISH for Eosinophilia


Eosinophilia is a chronic disorder resulting from excessive production of a particular type of white blood cells found in blood or body tissues. Eosinophils are produced in the bone marrow existing normally in the bloodstream and gut lining, which helps the body fight infection from parasitic organisms. On an average around 5% to 7% of white blood cells constitute eosinophils but if you have a higher count then it means that you either have borderline eosinophilia or actual progressing eosinophilia that can cause significant health hazards.

There are a variety of disorders that can cause eosinophilia ranging from simple hay fever to life threatening tumors. Most common cause for eosinophilia are parasitic infections (such as hookworm, schistosomiasis), allergic conditions (such asthma and hay fever), certain malignant tumors like lymphoma, inflammation of blood vessels, and certain types of drug reactions.

Common chromosome changes:

FIPIL1/PDGFRA 4q12 rearrangement
PDGFRB 5q33 rearrangement
FGFR1/CEP8 8p12 rearrangement
CBFB inv(16)/t(16;16)

Methodology: Fluorescent in Situ Hybridization (FISH) Analysis

Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment

ICD-10 Code: D72.1

Test Requisition: Cancer Requisition

Turn-around-time: 2-5 days

Specimen Requirements

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Contact Information
Genetics Laboratory
University of Oklahoma Health Sciences Center
1122 NE 13 Street, Suite 1400, Oklahoma City, OK 73104
Phone: (405) 271-3589 |Fax: (405) 271-7117 Email: Dr. Shibo Li

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