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Newborn Hypotonia Panel


Hypotonia is a state of low muscle tone often involving reduced muscle strength. Hypotonia is not a specific medical disorder, but a potential manifestation of many different diseases and disorders that affect motor nerve control by the brain or muscle strength. Recognizing hypotonia, even in early infancy, is usually relatively straightforward, but diagnosing the underlying cause can be difficult.

Infants who suffer from hypotonia are often described as feeling and appearing as though they are “rag dolls” easily slipping through one's hands. They are unable to maintain flexed ligaments, and are able to extend them beyond normal lengths. Often, the movement of the head is uncontrollable. Hypotonic infants often have difficulty feeding, as their mouth muscles cannot maintain a proper suck-swallow pattern, or a good breastfeeding latch.

Methodology: PWS methylation, SMA, DM1

Purpose: Confirmation of Clinical Diagnosis

ICD-10 Codes G70.89, P94.2

Test Requisition: Molecular Requisition

CPT Codes: 81331, 81400, 81401 Cost: $1252.00 (Oklahoma Medicaid requires preauthorization for SMA and DM1 only)

Turn-around-time: 21 days

Specimen Requirements

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Contact Information
Genetics Laboratory
University of Oklahoma Health Sciences Center
1122 NE 13 Street, Suite 1400, Oklahoma City, OK 73104
Phone: (405) 271-3589 |Fax: (405) 271-7117 Email: Dr. Shibo Li

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