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Myelodysplastic syndrome (MDS) is a group of bone marrow disorders characterized by the underproduction of one or more types of blood cells due to a dysfuntion of the marrow. The myelodysplastic syndromes (MDS) may be secondary to treatment with chemotherapy or radiation therapy for another disease.

MDS is characterized by low red blood cells (anemia), low white blood cell count (leukopenia) with a tendency to infection, and low platelet count (thrombocytopenia) with bleeding problems. MDS may progress and transform into acute myelogenous leukemia (AML).

Common chromosome changes would include:

EGR1/D5S630 -5/del(5q)
CEP//D7S486 -7/del(7q)
CEP8 trisomy 8
D13S319/LAMP1 -13/del(13q)
D20S108 -20/del(20q)
EVI1 inv(3)/t(3;3)

Methodology: Fluorescent in Situ Hybridization (FISH) Analysis

Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment

ICD-10 Code: D46.C/D46.9

Test Requisition: Cancer Requisition

Turn-around-time: 2-5 days

Specimen Requirements

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Contact Information
Genetics Laboratory
University of Oklahoma Health Sciences Center
1122 NE 13 Street, Suite 1400, Oklahoma City, OK 73104
Phone: (405) 271-3589 |Fax: (405) 271-7117 Email: Dr. Shibo Li

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