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FISH for Multiple Myeloma


Multiple Myeloma, also known as plasma cell myeloma, is usually seen in older adults. Patients present with osteolytic bone lesions, bone marrow infiltration and monoclonal gammopathy. A normal individual can synthesize the five classes of immunoglobulin but a patient with multiple myeloma produces a single immunoglobulin to excess and the synthesis of normal immunoglobulins is suppressed. Thus, the patient is said to have monoclonal gammopathy.

Common chromosome changes associated with Multiple Myeloma:

IGHG1 14q32 rearrangement
IGHG1/c-MAF t(14;16)
IGHG1/FGFR3 t(4;14)
CCND1/IGHG1 t(11;14)
TP53/CEP17 -17/del(17p)
RB1/LAMP1 -13/del(13q)
CEP9/CEP15 trisomy 9,15
CEP3/CEP7 trisomy 3,7
1q21 gain

Methodology: Fluorescent in Situ Hybridization (FISH) Analysis

Purpose: Confirmation of Clinical Diagnosis/Monitor During Treatment

ICD-10 Code: C90.00

Test Requisition: Cancer Requisition

Turn-around-time: 2-5 days

Specimen Requirements

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Contact Information
Genetics Laboratory
University of Oklahoma Health Sciences Center
1122 NE 13 Street, Suite 1400, Oklahoma City, OK 73104
Phone: (405) 271-3589 |Fax: (405) 271-7117 Email: Dr. Shibo Li

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