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Pancreatic Cancer PALB2


Pancreatic cancer refers to a malignant neoplasm originating from transformed cells arising in tissues that form the pancreas. The most common type of pancreatic cancer, accounting for 95% of these tumors, is adenocarcinoma arising within the exocrine component of the pancreas. A minority arise from islet cells, and are classified as neuroendocrine tumors. The symptoms that lead to diagnosis depend on the location, the size, and the tissue type of the tumor.

PALB2 (partner and localizer of BRCA2). This gene contains the information to make the PALB2 protein. This protein works together with the BRCA2 protein to repair damaged DNA. The PALB2 protein is believed to stabilize the BRCA2 protein, allowing the BRCA2 protein to repair damaged DNA. It was recently discovered that about 3% of patients with familial pancreatic cancer have inherited mutations in the PALB2 gene.

Chromosome locus 16p12.2

Methodology: Sequencing of entire coding region

Purpose: Confirmation of Clinical Diagnosis/Carrier Testing

ICD-10 Code C25.9

Test Requisition: Sequencing Requisition

CPT Code: 81406 Cost: $825.00

Turn-around-time: 5-6 weeks

Specimen Requirements

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Contact Information
Genetics Laboratory
University of Oklahoma Health Sciences Center
1122 NE 13 Street, Suite 1400, Oklahoma City, OK 73104
Phone: (405) 271-3589 |Fax: (405) 271-7117 Email: Dr. Shibo Li

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